![]() ![]() 3.1 Atropine in the Active Site of Phospholipase A2Ītropine is part of the tropane group alkaloid family, which includes other substances such as cocaine.3 Interaction of Atropine with Phospholipase A2.2.2 Considerations when taking Atropine.1.2 Inhibition of Acetylcholine Receptors.It can be given orally, intravenously, rectally, or subcutaneously (in animals). It has since been studied extensively and, although it is inherently poisonous, it is now used for a wide spectrum of medical ailments. It was also used by Cleopatra and women in the Renaissance era to dilate their pupils to give them a more beautiful appearance. Its first recorded use was in the 4th year of B.C.E, where it was used to treat wounds, gout, sleeplessnes, and was even thought to be a love potion. Īs a plant compound, Atropine has been used for hundreds of years. In humans, atropine is metabolized approximately 50%, hydrolyzed to tropine and toropic acid, and the remaining unchanged drug is excreted in the urine. It is a competitive antagonist of both acetylcholine receptors and phospholipase 2A and has a variety of effects on both humans and animals. It's chemical name is 8-methyl-8-azabicycolooct-3-yl) 3-hydroxy-2-phenylpropanoate, and the most common medicinal form of atropine is atrophine sulfate ((C17H23NO3)2 Atropine is an alkaloid drug derived from levohyscocyamine, a plant compound found in the family Solanaceae.
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